Six cases out of 19 Anti-Retroviral treatment naοve patients developed cryptococcal meningitis as a result of Immune reconstitution inflammatory syndrome. Hepatitis B virus and HCV co-infection was found in 2 and 5 cases respectively. Commonest co-opportunistic infection was tuberculosis (n = 8). India ink was positive in CSF examination in 74 (83.1%) cases while CSF and serum CALA were positive in 84.3% and 100% cases respectively.Mean CD4T-cell count was 44.64 ± 25.3. Causative species of Cryptococcus strains were Cryptococcus neoformans in 86 cases and Cryptococcus albidus in 3 cases. CSF findings were suggestive of chronic meningitis in 71 (78.86%) cases. Age ranged from 21 years to 61 years (Male:Female = 3.4:1). Results : Out of 391 AIDS cases, 89 had cryptococcal meningitis. Routine cerebrospinal fluid (CSF) analysis, India ink preparation, cryptococcal antigen latex agglutination (CALA), adenosine deaminase, Vitek-2 technology for species identification, culture, and sensitivity for CSF, serum CALA, skin scraping, fine needle aspiration cytology from lymph nodes, sputum for Acid Fast Bacillus, Cryptococcus by Giemsa stain, computed tomography scan/magnetic resonance imaging brain, CD 4 T-cell count, HbsAg, Hepatitis C Virus-Ab and Venereal Disease Research Laboratory test were done for all patients. Materials and Methods: AIDS cases admitted in the medicine ward of Regional Institute of Medical Sciences, Imphal from July 2003 to June 2011, with signs and symptoms of meningitis were included in the study. Objectives : To study the profile of cryptococcal meningitis in acquired immunodeficiency syndrome (AIDS) patients.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |